I had so much inflammation in my knee joint ... going all the way down my leg into my heel nearly 3 years after a fall. It had gotten to the point where I couldn't go out for my daily walk, take the stairs, so housework, go grocery shopping ... all I wanted to do was sit down! Then, literally, the only bottle of this in a discount store fell into my hands. Truly, it was dropped there by my angel!! I found this roll-on right when I needed it. I was so frustrated, I had about given up! At first, I had to use it 3x/day, then twice. Weeks later, it has worked so well, I sometimes only need to use it once/day. But I don't ever want to be without it! What a difference it has made -- not just in terms of my physical wellbeing, but also my outlook! I hope it doesn't become so pricey that I can no longer afford it. That's my only concern!! Great stuff!!!